Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.42 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.42 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22669012 | 0.98 | NOTUM (0.48) | NOTUMARKDRSRPK2SRPK1 | |
| SCHEMBL30582931 | 0.89 | NOTUM (0.42) | NOTUMARKDRSRPK2SRPK1 | |
| SCHEMBL30582874 | 0.89 | NOTUM (0.42) | NOTUMARKDRSRPK2SRPK1 | |
| SCHEMBL30582898 | 0.87 | NOTUM (0.40) | NOTUMARKDRSRPK2SRPK1 | |
| SCHEMBL30582873 | 0.87 | NOTUM (0.40) | NOTUMARKDRSRPK2SRPK1 | |
| SCHEMBL24008739 | 0.86 | NOTUM (0.47) | NOTUMARKDRSRPK2SRPK1 | |
| SCHEMBL22657890 | 0.79 | PIM2 (0.39) | NOTUMGAAKMT2A | |
| SCHEMBL28705798 | 0.79 | PIM2 (0.39) | NOTUMGAAKMT2A | |
| SCHEMBL27307160 | 0.77 | CYP46A1 (0.40) | ARTRPV1GAAKMT2ACNR2 | |
| SCHEMBL30582883 | 0.76 | NOTUM (0.42) | NOTUMKDRSRPK2SRPK1SRPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224864-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2021-11-11 | — | — | WO | disclosed |
| WO-2020229968-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2020-11-19 | — | — | WO | disclosed |