Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.48 |
| ▸ | CHKA | P35790 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.40 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22668992 | 0.98 | NOTUM (0.47) | NOTUMCHKATRPV1ARMAPT | |
| SCHEMBL30582931 | 0.91 | NOTUM (0.42) | NOTUMCHKATRPV1ARMAPT | |
| SCHEMBL30582874 | 0.91 | NOTUM (0.42) | NOTUMCHKATRPV1ARMAPT | |
| SCHEMBL30582873 | 0.89 | NOTUM (0.40) | NOTUMCHKATRPV1ARMAPT | |
| SCHEMBL30582898 | 0.89 | NOTUM (0.40) | NOTUMCHKATRPV1ARMAPT | |
| SCHEMBL24008739 | 0.84 | NOTUM (0.47) | NOTUMCHKATRPV1ARMAPT | |
| SCHEMBL22657890 | 0.81 | PIM2 (0.39) | NOTUMKMT2AGAA | |
| SCHEMBL28705798 | 0.81 | PIM2 (0.39) | NOTUMKMT2AGAA | |
| SCHEMBL27307160 | 0.79 | CYP46A1 (0.40) | TRPV1ARKMT2AMEN1CYP1A2 | |
| SCHEMBL30582883 | 0.78 | NOTUM (0.42) | NOTUMCHKATRPV1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224864-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2021-11-11 | — | — | WO | disclosed |
| WO-2020229968-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2020-11-19 | — | — | WO | disclosed |