SCHEMBL22669129

SCHEMBL22669129

NCc1csc(C[C@H](N)C(=O)O)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 4/20 0.40
▸ USP2 O75604 3/20 0.40
▸ PKM P14618 2/20 0.40
▸ CYP3A4 P08684 2/20 0.40
▸ ALOX15 P16050 2/20 0.40
▸ HIF1A Q16665 2/20 0.40
▸ KDM4E B2RXH2 2/20 0.40
▸ RECQL P46063 2/20 0.40
▸ TDP1 Q9NUW8 2/20 0.40
▸ RGS12 O14924 1/20 0.40
▸ CYP2C9 P11712 1/20 0.40
▸ NFKB1 P19838 1/20 0.40
▸ CASP1 P29466 1/20 0.40
▸ BRCA1 P38398 1/20 0.40
▸ THPO P40225 1/20 0.40
▸ CASP7 P55210 1/20 0.40
▸ GNAI1 P63096 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23295354 0.79 USP2 (0.41) HSD17B10USP2PKMCYP3A4ALOX15
SCHEMBL25222631 0.79 USP2 (0.41) HSD17B10USP2PKMCYP3A4ALOX15
SCHEMBL23295357 0.79 USP2 (0.41) HSD17B10USP2PKMCYP3A4ALOX15
SCHEMBL15469243 0.79 HSD17B10 (0.34) HSD17B10USP2PKMCYP3A4ALOX15
SCHEMBL8955092 0.73 HSD17B10 (0.59) HSD17B10USP2PKMCYP3A4ALOX15
SCHEMBL28694718 0.73 HSD17B10 (0.59) HSD17B10USP2PKMCYP3A4ALOX15
SCHEMBL15469205 0.73 CYP1A2 (0.37) HSD17B10PKMCYP3A4SLC7A5PTGS1
SCHEMBL7422906 0.72 F2 (0.51) —
SCHEMBL6092562 0.72 DPP4 (0.49) PKMTDP1ALDH1A1LMNAPOLB
SCHEMBL22189977 0.71 SLC7A5 (0.41) PKMHIF1AKDM4EMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230139442-A1 MODIFIED AMINO ACIDS SUTRO BIOPHARMA, INC. 2023-05-04 — — US disclosed
US-11548852-B2 Modified amino acids SUTRO BIOPHARMA, INC. (US) 2023-01-10 — — US disclosed
US-20200361870-A1 MODIFIED AMINO ACIDS SUTRO BIOPHARMA, INC. 2020-11-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200361870-A1 MODIFIED AMINO ACIDS PTMS, DNPEP, ANPEP HSD17B10 4458/4885USP2 1122/4885PKM 4111/4885
US-11548852-B2 Modified amino acids PTMS, DNPEP, ANPEP HSD17B10 4458/4885USP2 1122/4885PKM 4111/4885
US-20230139442-A1 MODIFIED AMINO ACIDS PTMS, DNPEP, ANPEP HSD17B10 4458/4885USP2 1122/4885PKM 4111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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