SCHEMBL15469205

SCHEMBL15469205

[N-]=[N+]=NCc1nc(C[C@H](N)C(=O)O)cs1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 1/20 0.37
▸ SLC7A5 Q01650 3/20 0.33
▸ PKM P14618 2/20 0.33
▸ ALPI P09923 1/20 0.33
▸ PTGS1 P23219 1/20 0.33
▸ XIAP P98170 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.32
▸ CYP3A4 P08684 1/20 0.32
▸ HDAC1 Q13547 2/20 0.32
▸ HDAC6 Q9UBN7 2/20 0.32
▸ GRIA1 P42261 2/20 0.31
▸ GRIA2 P42262 2/20 0.31
▸ GRIA3 P42263 2/20 0.31
▸ GRIA4 P48058 2/20 0.31
▸ GRIK1 P39086 1/20 0.31
▸ SLC1A3 P43003 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15469243 0.90 HSD17B10 (0.34) CYP1A2SLC7A5PKMALPIPTGS1
SCHEMBL16644962 0.78 HDAC1 (0.42) HDAC1HDAC6
SCHEMBL15469203 0.76 CYP1A2 (0.48) CYP1A2SLC7A5PKMALPIPTGS1
SCHEMBL20536570 0.73 PGK1 (0.39) —
SCHEMBL22669129 0.73 HSD17B10 (0.40) CYP1A2SLC7A5PKMALPIPTGS1
SCHEMBL15417769 0.72 SLC6A3 (0.33) —
SCHEMBL8955092 0.72 HSD17B10 (0.59) CYP1A2SLC7A5PKMALPIPTGS1
SCHEMBL28694718 0.72 HSD17B10 (0.59) CYP1A2SLC7A5PKMALPIPTGS1
SCHEMBL15469228 0.72 SLC7A5 (0.41) CYP1A2SLC7A5PKMALPIPTGS1
SCHEMBL20751484 0.71 HDAC6 (0.39) HSD17B10HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA INC (US) 2024-01-25 — — US disclosed
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA INC (US) 2024-01-25 — — US disclosed
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof SUTRO BIOPHARMA, INC. (US) 2023-09-05 — — US disclosed
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof SUTRO BIOPHARMA, INC. (US) 2023-09-05 — — US disclosed
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates SUTRO BIOPHARMA, INC. (US) 2023-07-25 — — US disclosed
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates SUTRO BIOPHARMA, INC. (US) 2023-07-25 — — US disclosed
US-20230139442-A1 MODIFIED AMINO ACIDS SUTRO BIOPHARMA, INC. 2023-05-04 — — US disclosed
US-20230139442-A1 MODIFIED AMINO ACIDS SUTRO BIOPHARMA, INC. 2023-05-04 — — US disclosed
US-11548852-B2 Modified amino acids SUTRO BIOPHARMA, INC. (US) 2023-01-10 — — US disclosed
EP-4074728-A1 MODIFIED PEPTIDES COMPRISING AN AZIDO GROUP Sutro Biopharma, Inc. (US) 2022-10-19 — — EP disclosed
US-20160251336-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2016-09-01 — — US disclosed
US-20160251336-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2016-09-01 — — US disclosed
WO-2015006555-A2 ANTIBODIES COMPRISING MULTIPLE SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2015-01-15 — — WO disclosed
US-20140066598-A1 Modified Amino Acids SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — US disclosed
WO-2014036492-A1 MODIFIED AMINO ACIDS COMPRISING AN AZIDO GROUP SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — WO disclosed
US-20140066598-A1 Modified Amino Acids SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — US disclosed
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use SUTRO BIOPHARMA, INC. 2014-02-20 — — US disclosed
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use SUTRO BIOPHARMA, INC. 2014-02-20 — — US disclosed
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2014-02-13 — — US disclosed
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2014-02-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use FCGR2A, FCGR3B, FCGR1A CYP1A2 4625/4885SLC7A5 888/4885PKM 4631/4885
US-11548852-B2 Modified amino acids PTMS, DNPEP, ANPEP CYP1A2 4794/4885SLC7A5 80/4885PKM 4111/4885
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES CD74, CD63, CD99 CYP1A2 2991/4885SLC7A5 2691/4885PKM 4766/4885
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates CD74, CD63, CD99 CYP1A2 2827/4885SLC7A5 2703/4885PKM 4766/4885
US-20140066598-A1 Modified Amino Acids PTMS, DNPEP, ANPEP CYP1A2 4794/4885SLC7A5 80/4885PKM 4111/4885
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof FCGR1A, FCGR2A, FCGRT CYP1A2 2824/4885SLC7A5 3848/4885PKM 4449/4885
US-20230139442-A1 MODIFIED AMINO ACIDS PTMS, DNPEP, ANPEP CYP1A2 4794/4885SLC7A5 80/4885PKM 4111/4885
US-20160251336-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE DNPEP, SLC1A5, AADAT CYP1A2 3452/4885SLC7A5 14/4885PKM 2906/4885
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE DNPEP, LNPEP, ANPEP CYP1A2 4874/4885SLC7A5 310/4885PKM 4505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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