Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 11/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20999727 | 0.94 | ATF4 (0.51) | ATF4MAPTGRIN1GRIN2BALDH1A1 | |
| SCHEMBL20999264 | 0.90 | ATF4 (0.54) | ATF4MEN1KMT2AGRIN1GRIN2B | |
| SCHEMBL20999664 | 0.90 | ATF4 (0.54) | ATF4MEN1KMT2AGRIN1GRIN2B | |
| SCHEMBL20999273 | 0.90 | ATF4 (0.54) | ATF4MEN1KMT2AGRIN1GRIN2B | |
| SCHEMBL20999780 | 0.89 | GRIN1 (0.47) | ATF4MAPTMEN1KMT2AGRIN1 | |
| SCHEMBL20999239 | 0.89 | ATF4 (0.52) | ATF4MEN1KMT2AALDH1A1 | |
| SCHEMBL20999722 | 0.89 | ATF4 (0.52) | ATF4MAPTMEN1KMT2AGRIN1 | |
| SCHEMBL20999382 | 0.89 | ATF4 (0.52) | ATF4MAPTMEN1KMT2AGRIN1 | |
| SCHEMBL20999704 | 0.88 | ATF4 (0.51) | ATF4MEN1KMT2AALDH1A1 | |
| SCHEMBL22669148 | 0.88 | ATF4 (0.51) | ATF4MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200361941-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361941-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ATF4 1/4885MAPT 3293/4885MEN1 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.