Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22669515 | 0.92 | HPGD (0.48) | HPGDALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL22669496 | 0.92 | TP53 (0.49) | HPGDGAAALDH1A1KMT2AHTT | |
| SCHEMBL22669318 | 0.91 | HPGD (0.49) | HPGDPRMT5WDR77GAAALDH1A1 | |
| SCHEMBL22669325 | 0.90 | PRMT5 (0.48) | HPGDPRMT5WDR77GAAALDH1A1 | |
| SCHEMBL22669692 | 0.90 | PRMT5 (0.48) | HPGDPRMT5WDR77GAAALDH1A1 | |
| SCHEMBL20999090 | 0.90 | PRMT5 (0.48) | HPGDPRMT5WDR77GAAALDH1A1 | |
| SCHEMBL20999725 | 0.89 | PRMT5 (0.55) | HPGDPRMT5WDR77GAAALDH1A1 | |
| SCHEMBL20999677 | 0.87 | ATF4 (0.51) | PRMT5WDR77ALDH1A1LMNA | |
| SCHEMBL20999084 | 0.87 | ATF4 (0.51) | PRMT5WDR77ALDH1A1LMNA | |
| SCHEMBL22669272 | 0.87 | ATF4 (0.51) | PRMT5WDR77ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200361941-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361941-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | HPGD 849/4885PRMT5 2508/4885WDR77 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.