Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 10/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | LCK | P06239 | 5/20 | 0.48 |
| ▸ | TEK | Q02763 | 5/20 | 0.48 |
| ▸ | ABL1 | P00519 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | ABL2 | P42684 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | EIF2AK3 | Q9NZJ5 | 4/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18044717 | 0.84 | KDR (0.59) | METAXLSRCFLT3KDR | |
| SCHEMBL2074938 | 0.83 | KDR (0.64) | SRCFLT3KDRLCKTEK | |
| SCHEMBL23917434 | 0.82 | SRC (0.61) | METAXLSRCFLT3KDR | |
| SCHEMBL26110170 | 0.82 | AXL (0.63) | METAXLSRCFLT3KDR | |
| SCHEMBL13020096 | 0.82 | SRC (0.69) | METAXLSRCFLT3KDR | |
| SCHEMBL30582589 | 0.82 | AXL (0.63) | METAXLSRCFLT3KDR | |
| SCHEMBL16202367 | 0.81 | SRC (0.67) | SRCKDRLCKTEKABL1 | |
| SCHEMBL25716224 | 0.80 | MET (0.51) | METAXLSRCFLT3KDR | |
| SCHEMBL22676745 | 0.80 | SRC (0.67) | SRCKDRLCKTEKABL1 | |
| SCHEMBL20351725 | 0.78 | MET (0.48) | METAXLSRCFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306529-A2 | FGFR INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |