Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14886856 | 0.71 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL420793 | 0.71 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL419794 | 0.70 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11047547 | 0.69 | SMN1; SMN2 (0.60) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL6931199 | 0.69 | KMT2A (0.52) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL443581 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL17290978 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL18770544 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL18770453 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL28585189 | 0.68 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020230134-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | METABOMED LTD (IL) | 2020-11-19 | — | — | WO | disclosed |