Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 3/20 | 0.49 |
| ▸ | CTSS | P25774 | 5/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17571450 | 1.00 | SYK (0.56) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL25380138 | 0.88 | SYK (0.52) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL22678934 | 0.86 | SYK (0.55) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL17571456 | 0.86 | SYK (0.55) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL19203452 | 0.85 | SYK (0.52) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL19435270 | 0.83 | KMT2A (0.49) | ATMMEN1KMT2ACA12OPRM1 | |
| SCHEMBL19455580 | 0.82 | AKT1 (0.52) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL17571438 | 0.82 | AKT1 (0.52) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL30802196 | 0.80 | SYK (0.50) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL15650625 | 0.79 | SYK (0.49) | SYKAKT1CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189043-B1 | THERAPEUTIC COMPOUNDS AS INHIBITORS OF THE OREXIN-1 RECEPTOR | C4X DISCOVERY LTD (GB) | 2020-11-18 | — | — | EP | disclosed |