Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17571399 | 0.84 | HCRTR1 (0.46) | — | |
| SCHEMBL19435259 | 0.84 | HCRTR1 (0.46) | — | |
| SCHEMBL21969950 | 0.80 | F10 (0.40) | F10TSHRMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL19435333 | 0.78 | TSHR (0.45) | TSHRMAPK1L3MBTL1SMN1; SMN2NPSR1 | |
| SCHEMBL19435365 | 0.77 | F10 (0.42) | F10TSHRSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL17559726 | 0.77 | F10 (0.42) | F10TSHRSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL17559595 | 0.76 | HCRTR1 (0.52) | — | |
| SCHEMBL17559596 | 0.76 | HCRTR1 (0.52) | — | |
| SCHEMBL19435313 | 0.75 | HCRTR1 (0.43) | TSHRMAPK1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL17571402 | 0.75 | HCRTR1 (0.43) | TSHRMAPK1SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189043-B1 | THERAPEUTIC COMPOUNDS AS INHIBITORS OF THE OREXIN-1 RECEPTOR | C4X DISCOVERY LTD (GB) | 2020-11-18 | — | — | EP | disclosed |