Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.47 |
| ▸ | KDM6B | O15054 | 3/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22682056 | 0.97 | KDM4C (0.47) | KDM4CKDM6BHTR1DRXRARXRB | |
| SCHEMBL22682112 | 0.90 | KDM4C (0.43) | KDM4CKDM6BRXRARXRBRXRG | |
| SCHEMBL22682242 | 0.87 | KDM4C (0.43) | KDM4CKDM6BRXRARXRBRXRG | |
| SCHEMBL22681745 | 0.84 | KDM4C (0.45) | KDM4CKDM6BHTR1DKCNH2 | |
| SCHEMBL22744420 | 0.83 | LSS (0.44) | KDM4CRXRARXRBRXRGSLC18A3 | |
| SCHEMBL23917459 | 0.77 | KDM4C (0.39) | KDM4CHTR1DHPGDKCNH2HRH3 | |
| SCHEMBL22682835 | 0.77 | KDM4C (0.43) | KDM4CKDM6BHTR1DKCNH2 | |
| SCHEMBL22681906 | 0.76 | KDM4C (0.45) | KDM4CKDM6BSMN1; SMN2 | |
| SCHEMBL22681798 | 0.75 | RXRA (0.43) | KDM4CKDM6BRXRARXRBRXRG | |
| SCHEMBL22681929 | 0.74 | RXRA (0.43) | KDM4CRXRARXRBRXRGHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160952-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2020-12-02 | — | — | EP | disclosed |
| EP-3741749-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| EP-3738960-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-11-18 | — | — | EP | disclosed |