Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 2/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.53 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.53 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.53 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.53 |
| ▸ | CPN1 | P15169 | 3/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2268358 | 1.00 | SLC6A1 (0.53) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL25661085 | 1.00 | SLC6A1 (0.53) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL1309969 | 0.89 | CPN1 (0.62) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL1062937 | 0.89 | CPN1 (0.62) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL25358028 | 0.89 | CPN1 (0.58) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL2749798 | 0.89 | CPN1 (0.58) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL160000 | 0.89 | CPN1 (0.58) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL1800252 | 0.85 | SLC6A1 (0.48) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL1800254 | 0.85 | SLC6A1 (0.48) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL24740306 | 0.85 | SLC6A1 (0.48) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445440-B2 | Dimeric IAP inhibitors | NOVARTIS AG (CH) | 2013-05-21 | — | — | US | disclosed |
| EP-2539333-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104266-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | SLC6A1 4799/4885GABRA5 4526/4885GABRB2 3818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.