Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22685060 | 0.87 | WDR91 (0.45) | DEGS1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22439054 | 0.84 | DEGS1 (0.46) | DEGS1NAAAROCK2ROCK1EGLN1 | |
| SCHEMBL22684815 | 0.79 | LRRK2 (0.41) | DEGS1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL7277131 | 0.76 | MCHR1 (0.50) | KDM4EALDH1A1MAPTJAK2HPGD | |
| SCHEMBL22685090 | 0.74 | CD274 (0.43) | DEGS1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685186 | 0.74 | PTPN1 (0.48) | DEGS1KDM4ELMNAPTPN1HDAC3 | |
| SCHEMBL1169047 | 0.74 | PTPN1 (0.50) | KDM4EALDH1A1MAPTPTPN1CA1 | |
| SCHEMBL22685369 | 0.73 | HDAC1 (0.43) | DEGS1MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL22685202 | 0.73 | WDR91 (0.40) | HDAC3HDAC1HDAC2HDAC6EGLN1 | |
| SCHEMBL23908262 | 0.72 | EGLN1 (0.50) | DEGS1NAAAROCK2ROCK1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |