Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.62 |
| ▸ | CDK4 | P11802 | 13/20 | 0.62 |
| ▸ | PLK1 | P53350 | 2/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.59 |
| ▸ | AURKA | O14965 | 8/20 | 0.53 |
| ▸ | CDK9 | P50750 | 8/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.53 |
| ▸ | CDK1 | P06493 | 6/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | WEE1 | P30291 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22684873 | 0.84 | CDK2 (0.66) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL210175 | 0.79 | CDK4 (0.54) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL2283342 | 0.78 | CDK2 (0.77) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL1939585 | 0.78 | CDK4 (0.52) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL3661251 | 0.77 | CDK4 (0.57) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL22684842 | 0.77 | CDK4 (0.76) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL4799684 | 0.76 | CDK2 (0.78) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL2076190 | 0.76 | CDK2 (0.78) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL2073680 | 0.76 | CDK2 (0.78) | CDK2CDK4PLK1CCNE1AURKA | |
| SCHEMBL4797791 | 0.76 | CDK2 (0.78) | CDK2CDK4PLK1CCNE1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740484-B1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2024-09-11 | — | — | EP | disclosed |
| CN-111757881-B | 5- (Pyrimidin-4-yl) thiazol-2-yl urea derivatives as therapeutic agents | 澳升医药公司 | 2024-05-07 | — | — | CN | disclosed |
| US-20230092876-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2023-03-23 | — | — | US | disclosed |
| US-11325900-B2 | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents | AUCENTRA HOLDINGS PTY LTD (AU) | 2022-05-10 | — | — | US | disclosed |
| US-20210070746-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2021-03-11 | — | — | US | disclosed |
| EP-3740484-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | AUCENTRA HOLDINGS PTY LTD (AU) | 2020-11-25 | — | — | EP | disclosed |
| CN-111757881-A | 5- (pyrimidin-4-yl) thiazol-2-ylurea derivatives as therapeutic agents | 澳升控股有限公司 | 2020-10-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230092876-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | CDK8, CDK18, CDK9 | CDK2 8/4885CDK4 13/4885PLK1 101/4885 |
| US-11325900-B2 | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents | CDK8, CDK18, CDK9 | CDK2 8/4885CDK4 13/4885PLK1 101/4885 |
| US-20210070746-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | CDK8, CDK18, CDK9 | CDK2 8/4885CDK4 13/4885PLK1 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.