SCHEMBL2268490

SCHEMBL2268490

OCC(O)C(O)Cc1cnc(C(O)C(O)C(O)CO)cn1

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6735837 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL6740673 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL6871599 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL6740962 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL6740679 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL6741902 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL6741681 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL30949390 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL6741941 1.00 LMNA (0.32) LMNAL3MBTL1TDP1
SCHEMBL7984643 0.91

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040209890-A1 Polyhydroxyalkylpyrazine derivatives, their preparation and medicaments comprising them BASHIARDES GEORGES 2004-10-21 US claimed
EP-0998465-B1 POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM AVENTIS PHARMA SA (FR) 2003-09-10 EP claimed
US-6392042-B1 ANTIDIABETIC AGENTS AVENTIS PHARMA S.A. (FR) 2002-05-21 US claimed
EP-1678290-B1 BEVERAGES AND FOODSTUFFS RESISTANT TO LIGHT INDUCED FLAVOUR CHANGES, PROCESSES FOR MAKING THE SAME, AND COMPOSITIONS FOR IMPARTING SUCH RESISTANCE HEINEKEN SUPPLY CHAIN BV (NL) 2017-09-06 EP disclosed
EP-1678290-B1 BEVERAGES AND FOODSTUFFS RESISTANT TO LIGHT INDUCED FLAVOUR CHANGES, PROCESSES FOR MAKING THE SAME, AND COMPOSITIONS FOR IMPARTING SUCH RESISTANCE HEINEKEN SUPPLY CHAIN BV (NL) 2017-09-06 EP disclosed
US-8445050-B2 Beverages and foodstuffs resistant to light induced flavor changes, processes for making the same, and compositions for imparting such resistance HEINEKEN SUPPLY CHAIN B.V. (NL) 2013-05-21 US disclosed
US-8445050-B2 Beverages and foodstuffs resistant to light induced flavor changes, processes for making the same, and compositions for imparting such resistance HEINEKEN SUPPLY CHAIN B.V. (NL) 2013-05-21 US disclosed
US-8445050-B2 Beverages and foodstuffs resistant to light induced flavor changes, processes for making the same, and compositions for imparting such resistance HEINEKEN SUPPLY CHAIN B.V. (NL) 2013-05-21 US disclosed
US-7989014-B2 Beverages and foodstuffs resistant to light induced flavour changes, processes for making the same, and compositions for imparting such resistance HEINEKEN SUPPLY CHAIN B.V. (NL) 2011-08-02 US disclosed
US-7989014-B2 Beverages and foodstuffs resistant to light induced flavour changes, processes for making the same, and compositions for imparting such resistance HEINEKEN SUPPLY CHAIN B.V. (NL) 2011-08-02 US disclosed
US-7989014-B2 Beverages and foodstuffs resistant to light induced flavour changes, processes for making the same, and compositions for imparting such resistance HEINEKEN SUPPLY CHAIN B.V. (NL) 2011-08-02 US disclosed
EP-1675938-A1 BEVERAGES AND FOODSTUFFS RESISTANT TO LIGHT INDUCED FLAVOUR CHANGES, PROCESSES FOR MAKING THE SAME, AND COMPOSITIONS FOR IMPARTING SUCH RESISTANCE Heineken Supply Chain B.V. (NL) 2006-07-05 EP disclosed
WO-2005030919-A1 BEVERAGES AND FOODSTUFFS RESISTANT TO LIGHT INDUCED FLAVOUR CHANGES, PROCESSES FOR MAKING THE SAME, AND COMPOSITIONS FOR IMPARTING SUCH RESISTANCE HEINEKEN SUPPLY CHAIN B.V. (NL) 2005-04-07 WO disclosed
WO-2005030920-A1 BEVERAGES AND FOODSTUFFS RESISTANT TO LIGHT INDUCED FLAVOUR CHANGES, PROCESSES FOR MAKING THE SAME, AND COMPOSITIONS FOR IMPARTING SUCH RESISTANCE HEINEKEN SUPPLY CHAIN B.V. (NL) 2005-04-07 WO disclosed
US-20040209890-A1 Polyhydroxyalkylpyrazine derivatives, their preparation and medicaments comprising them BASHIARDES GEORGES 2004-10-21 US disclosed
EP-0998465-B1 POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM AVENTIS PHARMA SA (FR) 2003-09-10 EP disclosed
EP-1001942-B1 POLYHYDROXYBUTYLPYRAZINES, THEIR PREPARATION AND MEDICINES CONTAINING THEM AVENTIS PHARMA SA (FR) 2003-06-25 EP disclosed
US-6392042-B1 ANTIDIABETIC AGENTS AVENTIS PHARMA S.A. (FR) 2002-05-21 US disclosed
US-6288066-B1 ANTIDIABETIC AGENTS; OXIDATION, HYDROLYSIS AVENTIS PHARMA S.A. (FR) 2001-09-11 US disclosed
CN-1264368-A Polyhydroxybutylpyrazines, process for their preparation and medicaments containing them RHONE POULENC RORER SA (FR) 2000-08-23 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040209890-A1 Polyhydroxyalkylpyrazine derivatives, their preparation and medicaments comprising them SLC5A2, HK2, HRH2 LMNA 4447/4885L3MBTL1 4794/4885TDP1 4417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.