Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TYMP | P19971 | 13/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027678 | 0.76 | TYMP (0.46) | ALDH1A1KDM4EGAATYMPATM | |
| SCHEMBL28263643 | 0.73 | TYMP (0.43) | ALDH1A1KDM4EGAATYMPATM | |
| SCHEMBL27816353 | 0.73 | TYMP (0.45) | ALDH1A1KDM4EGAATYMPATM | |
| SCHEMBL4960409 | 0.70 | POLB (0.46) | ALDH1A1KDM4EGAATYMPATM | |
| SCHEMBL12702529 | 0.70 | TYMP (0.41) | ALDH1A1KDM4EGAATYMPATM | |
| SCHEMBL15469004 | 0.70 | POLB (0.43) | ALDH1A1KDM4EGAATYMPATM | |
| SCHEMBL8768819 | 0.68 | TYMP (0.44) | ALDH1A1KDM4ETYMPATMMEN1 | |
| SCHEMBL9191218 | 0.68 | ATM (0.44) | ALDH1A1KDM4EGAATYMPATM | |
| SCHEMBL30493068 | 0.68 | CRBN (0.36) | ALDH1A1KDM4EGAACRBNLMNA | |
| SCHEMBL4469664 | 0.67 | KDM4E (0.45) | ALDH1A1KDM4EGAATYMPATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795568-A1 | FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | Pharmakea, Inc. (US) | 2021-03-24 | — | — | EP | disclosed |
| EP-3265456-B1 | FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA INC (US) | 2020-11-18 | — | — | EP | disclosed |