Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19755660 | 0.81 | GRIA1 (0.43) | EGLN3TDO2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20942696 | 0.79 | EGLN3 (0.39) | EGLN3TDO2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23609758 | 0.73 | EGLN3 (0.46) | EGLN3ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL22212153 | 0.72 | — | — | |
| SCHEMBL23875663 | 0.72 | — | — | |
| SCHEMBL18072251 | 0.71 | ALDH1A1 (0.52) | ALDH1A1MAPTHTTPTGESKDM4E | |
| SCHEMBL12744441 | 0.71 | EGLN3 (0.44) | EGLN3ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL18072326 | 0.71 | EGLN3 (0.53) | EGLN3ALDH1A1MAPTSMN1; SMN2FDPS | |
| SCHEMBL27267342 | 0.71 | EGLN3 (0.42) | EGLN3ALDH1A1MAPTSMN1; SMN2CYP19A1 | |
| SCHEMBL27134470 | 0.71 | EGLN3 (0.52) | EGLN3ALDH1A1MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265456-B1 | FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA INC (US) | 2020-11-18 | — | — | EP | disclosed |