Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.41 |
| ▸ | KLK1 | P06870 | 2/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6860616 | 0.89 | HRH3 (0.49) | HRH3CACNA1GCACNA1HCACNA1IHRH1 | |
| SCHEMBL2270394 | 0.86 | HRH3 (0.49) | HRH3HRH1KLKB1KLK1 | |
| SCHEMBL2347977 | 0.86 | HRH3 (0.49) | HRH3HRH1KLKB1KLK1 | |
| SCHEMBL2193364 | 0.86 | HRH3 (0.45) | HRH3CACNA1GCACNA1HCACNA1IHRH1 | |
| SCHEMBL2365248 | 0.86 | HRH3 (0.49) | HRH3HRH1KLKB1KLK1 | |
| SCHEMBL2271409 | 0.85 | HRH3 (0.50) | HRH3CACNA1GCACNA1HCACNA1IHRH1 | |
| SCHEMBL2193394 | 0.83 | HRH3 (0.45) | HRH3HRH1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL2266847 | 0.81 | HRH3 (0.50) | HRH3HRH1KLKB1KLK1NAPEPLD | |
| SCHEMBL2269495 | 0.81 | HRH3 (0.50) | HRH3HRH1KLKB1KLK1NAPEPLD | |
| SCHEMBL2275230 | 0.81 | HRH3 (0.55) | HRH3HRH1PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011083315-A1 | COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | WO | claimed |
| WO-2011083315-A1 | COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011083315-A1 | COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | WO | disclosed |