Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 19/20 | 1.00 |
| ▸ | NLRP3 | Q96P20 | 7/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | TNF | P01375 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22654981 | 1.00 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL29508469 | 1.00 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL22689524 | 1.00 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL31329521 | 1.00 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL31329511 | 1.00 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL22655054 | 1.00 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL22654982 | 1.00 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL22654996 | 0.94 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL22654885 | 0.94 | IL1B (1.00) | IL1BNLRP3KCNH2TNF | |
| SCHEMBL22654948 | 0.94 | IL1B (1.00) | IL1BNLRP3KCNH2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3969441-A1 | NLRP3 INFLAMMASOME INHIBITORS | Novartis AG (CH) | 2022-03-23 | — | — | EP | claimed |
| WO-2020234715-A1 | NLRP3 INFLAMMASOME INHIBITORS | NOVARTIS AG (CH) | 2020-11-26 | — | — | WO | claimed |
| EP-3969441-A1 | NLRP3 INFLAMMASOME INHIBITORS | Novartis AG (CH) | 2022-03-23 | — | — | EP | disclosed |
| WO-2020234715-A1 | NLRP3 INFLAMMASOME INHIBITORS | NOVARTIS AG (CH) | 2020-11-26 | — | — | WO | disclosed |