Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 14/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2272771 | 0.92 | LRRK2 (0.43) | JAK2PTK2JAK3PSEN1PSEN2 | |
| SCHEMBL12453968 | 0.90 | PSEN1 (0.46) | JAK2PTK2JAK3PSEN1PSEN2 | |
| SCHEMBL17915480 | 0.88 | PSEN1 (0.56) | JAK2PTK2JAK3PSEN1PSEN2 | |
| SCHEMBL2272437 | 0.87 | PSEN1 (0.44) | JAK2PTK2JAK3PSEN1PSEN2 | |
| SCHEMBL2270370 | 0.86 | PSEN1 (0.46) | JAK2PTK2JAK3PSEN1PSEN2 | |
| SCHEMBL2274570 | 0.86 | PSEN1 (0.44) | JAK2PTK2JAK3PSEN1PSEN2 | |
| SCHEMBL2277703 | 0.85 | PSEN1 (0.46) | JAK2PTK2PSEN1PSEN2APH1B | |
| SCHEMBL2270873 | 0.85 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2274506 | 0.85 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2276377 | 0.84 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536710-B1 | PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-07-13 | — | — | EP | disclosed |
| US-8486967-B2 | Heteroaryl substituted piperidines | HOFFMANN-LA ROCHE INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-8486967-B2 | Heteroaryl substituted piperidines | HOFFMANN-LA ROCHE INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-8486967-B2 | Heteroaryl substituted piperidines | HOFFMANN-LA ROCHE INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | HOFFMANN-LA ROCHE, INC. | 2011-08-18 | — | — | US | disclosed |
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | HOFFMANN-LA ROCHE, INC. | 2011-08-18 | — | — | US | disclosed |
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | HOFFMANN-LA ROCHE, INC. | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | APP, HPGDS, PSEN1 | JAK2 3153/4885PTK2 1849/4885JAK3 4312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.