Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 10/20 | 0.49 |
| ▸ | TNF | P01375 | 5/20 | 0.49 |
| ▸ | IL1B | P01584 | 3/20 | 0.49 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20880770 | 0.89 | CRBN (0.54) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL20169760 | 0.86 | CRBN (0.53) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL19222305 | 0.86 | CRBN (0.42) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL18975490 | 0.85 | CRBN (0.51) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL24243428 | 0.83 | CRBN (0.49) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL19222087 | 0.83 | CRBN (0.49) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL20459068 | 0.82 | CRBN (0.51) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL20879678 | 0.82 | LMNA (0.41) | ALDH1A1SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL19171822 | 0.81 | CRBN (0.57) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL24137895 | 0.80 | CRBN (0.49) | CRBNIKZF3TNFIL1BIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741372-A1 | (S)-3-[4-(4-MORPHLIN-4-YLMETHYLBENZYLOXY)-1- OXO-1,3-DIHYDRO-ISOINDO-2-YL]PIPERIDINE-2,6-DIONE FOR USE IN THE TREATMENT OF IMMUNE-RELATED AND INFLAMMATORY DISEASES | Celgene Corporation (US) | 2020-11-25 | — | — | EP | disclosed |