Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30748657 | 1.00 | EGFR (0.58) | EGFRFLT3MKNK1MKNK2HDAC1 | |
| SCHEMBL29423844 | 0.88 | EGFR (0.58) | EGFRFLT3MKNK1MKNK2HDAC1 | |
| SCHEMBL22695238 | 0.88 | EGFR (0.58) | EGFRFLT3MKNK1MKNK2HDAC1 | |
| SCHEMBL30129425 | 0.85 | EGFR (0.59) | EGFRFLT3MKNK1MKNK2HDAC1 | |
| SCHEMBL30129517 | 0.84 | EGFR (0.68) | EGFRFLT3MKNK1MKNK2HDAC1 | |
| SCHEMBL30129482 | 0.83 | EGFR (0.59) | EGFRFLT3MKNK1MKNK2HDAC1 | |
| SCHEMBL22689068 | 0.80 | EGFR (0.76) | EGFRKDR | |
| SCHEMBL30129576 | 0.80 | EGFR (0.68) | EGFRFLT3MKNK1MKNK2HDAC1 | |
| SCHEMBL2547336 | 0.80 | EGFR (0.71) | EGFRFLT3MKNK1MKNK2HDAC1 | |
| SCHEMBL30129167 | 0.80 | EGFR (0.60) | EGFRFLT3MKNK1MKNK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112292378-B | Indole derivative-containing inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| EP-3974423-A1 | INDOLE DERIVATIVE-CONTAINING INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2022-03-30 | — | — | EP | disclosed |
| CN-112292378-A | Indole derivative-containing inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-01-29 | — | — | CN | disclosed |
| WO-2020233669-A1 | INDOLE DERIVATIVE-CONTAINING INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 (CN) | 2020-11-26 | — | — | WO | disclosed |