Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15445325 | 0.86 | ALDH1A1 (0.49) | ALDH1A1GAAHSD17B10POLBFOLH1 | |
| SCHEMBL15445339 | 0.86 | ALDH1A1 (0.49) | ALDH1A1GAAHSD17B10POLBFOLH1 | |
| SCHEMBL20115488 | 0.85 | ALDH1A1 (0.48) | ALDH1A1GAAHSD17B10POLBFOLH1 | |
| SCHEMBL20898143 | 0.84 | ITGB1 (0.47) | ALDH1A1GAAHSD17B10POLBFOLH1 | |
| SCHEMBL22693781 | 0.84 | ALDH1A1 (0.47) | ALDH1A1GAAHSD17B10POLBFOLH1 | |
| SCHEMBL29547598 | 0.84 | ITGB1 (0.47) | ALDH1A1GAAHSD17B10POLBFOLH1 | |
| SCHEMBL13957285 | 0.80 | MME (0.60) | FOLH1MMP2MMP9ADAMTS4MME | |
| SCHEMBL14999575 | 0.80 | ITGB1 (0.45) | ALDH1A1GAAHSD17B10POLBFOLH1 | |
| SCHEMBL2781126 | 0.79 | MME (0.58) | MMEACECPA1ACE2L3MBTL1 | |
| SCHEMBL15592756 | 0.79 | MME (0.58) | MMEACECPA1ACE2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200369652-A1 | PROCESSES FOR PREPARATION OF LIFITEGRAST AND INTERMEDIATES THEREOF | DR. REDDY'S LABORATORIES LIMITED (IN) | 2020-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369652-A1 | PROCESSES FOR PREPARATION OF LIFITEGRAST AND INTERMEDIATES THEREOF | LIFR, FLT3, CSF3R | ALDH1A1 2263/4885GAA 124/4885HSD17B10 3942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.