Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FABP6 | P51161 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22702143 | 0.84 | TP53 (0.42) | TP53EPHX2KDM1AEPHX1NPSR1 | |
| SCHEMBL774350 | 0.78 | ADH1B (0.50) | TP53EPHX2KDM1AEPHX1NPSR1 | |
| SCHEMBL29259766 | 0.77 | TP53 (0.48) | TP53EPHX2KDM1AEPHX1NPSR1 | |
| SCHEMBL18375610 | 0.71 | — | — | |
| SCHEMBL5344959 | 0.71 | TP53 (0.50) | TP53EPHX2KDM1AEPHX1NPSR1 | |
| SCHEMBL12820051 | 0.70 | TP53 (0.48) | TP53EPHX2KDM1AEPHX1NPSR1 | |
| SCHEMBL773447 | 0.68 | ADH1B (0.41) | TP53EPHX2KDM1AEPHX1NPSR1 | |
| SCHEMBL21746087 | 0.68 | TP53 (0.41) | TP53EPHX2KDM1AEPHX1NPSR1 | |
| SCHEMBL20609817 | 0.67 | TP53 (0.46) | TP53EPHX2KDM1AEPHX1NPSR1 | |
| SCHEMBL12404039 | 0.67 | TP53 (0.46) | TP53EPHX2KDM1AEPHX1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319955-B1 | 6-AMINO-QUINOLINE-3-CARBONITRILS AS COT MODULATORS | GILEAD SCIENCES INC (US) | 2020-11-25 | — | — | EP | disclosed |