Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24252062 | 0.82 | SLC6A4 (0.44) | PPARGPPARAPDE2ASLC6A4SLC6A2 | |
| SCHEMBL8549769 | 0.77 | SLC6A4 (0.41) | PPARGPPARAPDE2ASLC6A4SLC6A2 | |
| SCHEMBL1417566 | 0.75 | PPARA (0.56) | PPARGPPARAHSD11B1HSD11B2MRGPRX4 | |
| SCHEMBL8396955 | 0.74 | EPHX2 (0.50) | PPARGPPARAPDE2ASLC6A4SLC6A2 | |
| SCHEMBL2828182 | 0.74 | HSD11B1 (0.46) | PPARGPPARAPDE2AHSD11B1HSD11B2 | |
| SCHEMBL2824526 | 0.73 | SLC6A4 (0.41) | PPARGPPARAPDE2ASLC6A4SLC6A2 | |
| SCHEMBL17107500 | 0.73 | SLC6A4 (0.38) | PPARGPPARAPDE2ASLC6A4SLC6A2 | |
| SCHEMBL22688970 | 0.72 | HSD11B1 (0.44) | PPARGPPARAHSD11B1HSD11B2S1PR4 | |
| SCHEMBL7928216 | 0.72 | PPARG (0.41) | PPARGPPARAPDE2ASLC6A4SLC6A2 | |
| SCHEMBL23519094 | 0.71 | PPARA (0.51) | PPARGPPARAHSD11B1HSD11B2MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020233618-A1 | INHIBITORS FOR PROGRAMMED CELL NECROSIS AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海有机化学研究所 (CN) | 2020-11-26 | — | — | WO | disclosed |