Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.32 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570928 | 0.86 | PREP (0.39) | PREPCELA1KDM4EHSD17B10CA2 | |
| SCHEMBL29047018 | 0.84 | PREP (0.38) | PREPCELA1KDM4EHSD17B10CA2 | |
| SCHEMBL31634841 | 0.84 | PREP (0.38) | PREPCELA1KDM4EHSD17B10CA2 | |
| SCHEMBL21728696 | 0.82 | PREP (0.30) | PREPCELA1 | |
| SCHEMBL14962495 | 0.79 | PREP (0.39) | PREPCELA1KDM4EHSD17B10CA2 | |
| SCHEMBL29000115 | 0.78 | PREP (0.40) | PREPCELA1KDM4EHSD17B10CA2 | |
| SCHEMBL7879433 | 0.76 | CYP4F2 (0.37) | PREPCELA1KDM4EHSD17B10CA2 | |
| SCHEMBL24436816 | 0.76 | PREP (0.41) | PREPCELA1KDM4EHSD17B10CA2 | |
| SCHEMBL19605886 | 0.76 | KDM4E (0.36) | PREPCELA1KDM4EHSD17B10CA2 | |
| SCHEMBL24436825 | 0.76 | PREP (0.41) | PREPCELA1KDM4EHSD17B10CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115451-A1 | MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | NOVARTIS AG (CH) | 2022-06-02 | — | — | WO | disclosed |
| EP-3797797-A1 | ANTIBODY CONJUGATES COMPRISING TOLL-LIKE RECEPTOR AGONIST | Novartis AG (CH) | 2021-03-31 | — | — | EP | disclosed |
| WO-2020236825-A2 | MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | NOVARTIS AG (CH) | 2020-11-26 | — | — | WO | disclosed |