Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.57 |
| ▸ | IKZF2 | Q9UKS7 | 11/20 | 0.53 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22713530 | 1.00 | CRBN (0.57) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 | |
| SCHEMBL22713350 | 0.91 | CRBN (0.57) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 | |
| SCHEMBL22713354 | 0.91 | CRBN (0.57) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 | |
| SCHEMBL22713291 | 0.89 | CRBN (0.59) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 | |
| SCHEMBL22713295 | 0.89 | CRBN (0.59) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 | |
| SCHEMBL29486662 | 0.89 | CRBN (0.59) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 | |
| SCHEMBL22713284 | 0.89 | CRBN (0.61) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 | |
| SCHEMBL22713288 | 0.89 | CRBN (0.61) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 | |
| SCHEMBL22713505 | 0.89 | CRBN (0.63) | CRBNCSNK1A1IKZF2GSPT1DDB1 | |
| SCHEMBL22713500 | 0.87 | CRBN (0.55) | CRBNCSNK1A1IKZF2GSPT1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306101-B2 | Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith | CELGENE CORPORATION (US) | 2022-04-19 | — | — | US | claimed |
| US-20220213115-A1 | SUBSTITUTED 1-OXO-ISOINDOLINE-5-CARBOXAMIDE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORP (US) | 2022-07-07 | — | — | US | disclosed |
| US-20200377512-A1 | SUBSTITUTED 1-OXO-ISOINDOLINE-5-CARBOXAMIDE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377512-A1 | SUBSTITUTED 1-OXO-ISOINDOLINE-5-CARBOXAMIDE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CPT1A, GOT2, IDH2 | CRBN 1290/4885CSNK1A1 798/4885IKZF2 4021/4885 |
| US-20220213115-A1 | SUBSTITUTED 1-OXO-ISOINDOLINE-5-CARBOXAMIDE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CPT1A, GOT2, IDH2 | CRBN 1290/4885CSNK1A1 798/4885IKZF2 4021/4885 |
| US-11306101-B2 | Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith | CPT1A, GOT2, IDH2 | CRBN 1290/4885CSNK1A1 798/4885IKZF2 4021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.