Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22746590 | 0.89 | SMN1; SMN2 (0.44) | HDAC1SMN1; SMN2HDAC6HDAC3HDAC2 | |
| SCHEMBL22718538 | 0.88 | NPC1 (0.51) | HDAC1SMN1; SMN2KDM4EALDH1A1NR1H4 | |
| SCHEMBL22718570 | 0.87 | TP53 (0.45) | HDAC1SMN1; SMN2HDAC6HDAC3HDAC2 | |
| SCHEMBL22718553 | 0.86 | NR1H4 (0.60) | HDAC1NR1H4TRPV1MEN1KMT2A | |
| SCHEMBL22718633 | 0.85 | HDAC1 (0.49) | HDAC1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL22718579 | 0.85 | KCNK3 (0.50) | HDAC1SMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL22718572 | 0.83 | TRPV1 (0.54) | HDAC1LMNANR1H4TRPV1MAPT | |
| SCHEMBL24601223 | 0.83 | HDAC1 (0.46) | HDAC1SMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL22746508 | 0.83 | HDAC1 (0.46) | HDAC1NR1H4TRPV1 | |
| SCHEMBL6509337 | 0.78 | HDAC1 (0.71) | HDAC1SMN1; SMN2HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213052-A1 | INHIBITORS OF RNA-BINDING PROTEINS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEROF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2022-07-07 | — | — | US | disclosed |
| US-20220213052-A1 | INHIBITORS OF RNA-BINDING PROTEINS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEROF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2022-07-07 | — | — | US | disclosed |
| EP-3963085-A2 | INHIBITORS OF RNA-BINDING PROTEINS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEREOF | The University of North Carolina at Chapel Hill (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020242719-A2 | INHIBITORS OF RNA-BINDING PROTEINS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020242719-A2 | INHIBITORS OF RNA-BINDING PROTEINS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2020-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213052-A1 | INHIBITORS OF RNA-BINDING PROTEINS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEROF | HNRNPF, RBM3, RBM15 | HDAC1 1875/4885SMN1; SMN2 1704/4885HDAC6 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.