Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19140474 | 0.80 | KDM4E (0.45) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL29515403 | 0.80 | SMN1; SMN2 (0.39) | AURKAMAPK10RIPK1HSD17B10IGF1R | |
| SCHEMBL22718128 | 0.79 | HSD17B10 (0.37) | AURKAMAPK10RIPK1HSD17B10IGF1R | |
| SCHEMBL22029691 | 0.74 | ADORA1 (0.51) | AURKAMAPK10RIPK1HSD17B10KMT2A | |
| SCHEMBL22344793 | 0.73 | AURKA (0.47) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL17927711 | 0.73 | BRD4 (0.50) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL17338741 | 0.72 | PDK1 (0.46) | PDK1IGF1RCDK2FLT3CCNA1 | |
| SCHEMBL1808383 | 0.72 | AURKA (0.44) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL9148813 | 0.72 | AURKA (0.46) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL13070458 | 0.71 | ADORA1 (0.53) | AURKAMAPK10RIPK1HSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220242879-A1 | FUSED HETEROCYCLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2022-08-04 | — | — | US | disclosed |
| EP-3976620-A1 | FUSED HETEROCYCLIC DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-04-06 | — | — | EP | disclosed |
| CN-113906030-A | Fused heterocyclic derivatives | 爱尔兰詹森科学公司 | 2022-01-07 | — | — | CN | disclosed |
| WO-2020243153-A1 | FUSED HETEROCYCLIC DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220242879-A1 | FUSED HETEROCYCLE DERIVATIVES | HAVCR2, HCCS, CYP3A4 | PDK1 164/4885AURKA 638/4885MAPK10 2916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.