Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719925 | 0.88 | EGLN2 (0.41) | SMN1; SMN2EGLN2GAAEGLN1HDAC3 | |
| SCHEMBL29829420 | 0.87 | SMPD1 (0.45) | SMN1; SMN2EGLN2EGLN1HDAC3HDAC1 | |
| SCHEMBL12444334 | 0.85 | EGLN1 (0.41) | SMN1; SMN2EGLN1HDAC6NPC1RAB9A | |
| SCHEMBL22719952 | 0.84 | EPHX2 (0.41) | SMN1; SMN2EGLN1NPC1RAB9AALDH1A1 | |
| SCHEMBL22283896 | 0.83 | EGLN1 (0.47) | SMN1; SMN2EGLN1HDAC6NPC1RAB9A | |
| SCHEMBL22738417 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2EGLN1NPC1RAB9AALDH1A1 | |
| SCHEMBL22719898 | 0.76 | EGLN1 (0.39) | EGLN2EGLN1NPC1RAB9AMEN1 | |
| SCHEMBL2219007 | 0.75 | SMPD1 (0.44) | SMN1; SMN2EGLN2EGLN1HDAC3HDAC1 | |
| SCHEMBL1503276 | 0.75 | AR (0.40) | EGLN1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1503227 | 0.74 | HDAC6 (0.40) | SMN1; SMN2EGLN1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |