Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719898 | 0.89 | EGLN1 (0.39) | EGLN2EGLN1NPC1RAB9AKDM4E | |
| SCHEMBL2219007 | 0.89 | SMPD1 (0.44) | EGLN2EGLN1HDAC3HDAC1HDAC2 | |
| SCHEMBL22719957 | 0.88 | SMN1; SMN2 (0.42) | EGLN2EGLN1HDAC3HDAC1HDAC2 | |
| SCHEMBL12444335 | 0.85 | HTT (0.40) | EGLN1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13577624 | 0.83 | EGLN1 (0.40) | EGLN1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1503184 | 0.82 | MAOB (0.44) | EGLN1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL1503272 | 0.82 | NPC1 (0.52) | EGLN1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL22719946 | 0.81 | GAA (0.44) | EGLN2HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22738236 | 0.81 | EGLN1 (0.39) | EGLN2EGLN1NPC1RAB9AALDH1A1 | |
| SCHEMBL22283911 | 0.79 | NPC1 (0.39) | SMN1; SMN2NPC1RAB9ATP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |