Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL163831 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL12542739 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4020414 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL16685075 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11039957 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL23062790 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL15054707 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20607531 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20535729 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3164373 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 41081 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3836899-B1 | CHEMOTHERAPEUTIC PHARMACEUTICAL SUSPENSION FOR ORAL DOSAGE | ONCOSOL LTD (GB) | 2026-05-27 | — | — | EP | claimed |
| CN-122081995-A | Preparation method of perovskite oxygen evolution reaction catalyst activated by electric pulse | — | 2026-05-26 | — | — | CN | claimed |
| CN-121377849-B | Passivation culture solution for reducing cadmium in rice and preparation method thereof | Hunan Featured Rice Agriculture Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-116914099-B | Cobalt-free air electrode material for reversible proton conductor type ceramic electrochemical cell, and preparation and application thereof | SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) | 2026-05-26 | — | — | CN | claimed |
| US-12636262-B2 | Process for the preparation of topical formulation | Neuheit Pharma Technologies Pvt. Ltd. (IN) | 2026-05-26 | — | — | US | claimed |
| CN-122079766-A | Supercritical CO-based2Method for preparing ultra-high purity citric acid monohydrate | — | 2026-05-26 | — | — | CN | claimed |
| CN-122091533-A | Preparation method of high-entropy sodium ferrous sulfate/carbon composite positive electrode material and application of high-entropy sodium ferrous sulfate/carbon composite positive electrode material in high-temperature sodium ion battery | — | 2026-05-26 | — | — | CN | claimed |
| CN-121819797-B | Gasoline prehydrogenation toothed spherical alumina carrier and preparation method thereof | 临朐恒辉新材料有限公司 | 2026-05-22 | — | — | CN | claimed |
| CN-121609370-B | Preparation method of low-temperature high-crystallization samarium cobalt oxide perovskite oxide and application of low-temperature high-crystallization samarium cobalt oxide perovskite oxide in catalytic oxidation of toluene | 东北大学 | 2026-05-22 | — | — | CN | claimed |
| CN-122071418-A | Preparation method of salbutamol sulfate, salbutamol sulfate injection and preparation method of salbutamol sulfate injection | 海南皇隆制药股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| US-4407962-A | QUANTITATIVE ANALYSIS OF IRON IN BLOOD | Istituto Sieroteropico E. Vaccinogeno Toscano "Sclavo" S.p.A. (IT) | 1983-10-04 | — | — | US | claimed |
| EP-0066987-A2 | N-(aryloxyalkyl)-N'-(amino-alkyl) ureas | A.H. ROBINS COMPANY, INCORPORATED (US) | 1982-12-15 | — | — | EP | claimed |
| US-4328213-A | HYPOTENSIVE AGENTS, ANTIARRHTHYMIA AGENTS | SCHERING CORPORATION (US) | 1982-05-04 | — | — | US | claimed |
| EP-0012904-B1 | WINDSCREEN DETERGENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-04-07 | — | — | EP | claimed |
| US-4264470-A | Selecting goat erythrocytes to simulate human platelets in hematologic reference controls | COULTER ELECTRONICS, INC. (US) | 1981-04-28 | — | — | US | claimed |
| US-4105576-A | SPILL CONTROL COMPOSITION AND USE THEREOF | J. T. BAKER CHEMICAL COMPANY (US) | 1978-08-08 | — | — | US | claimed |
| US-4102799-A | PHOSPHATE-FREE, CONTAINS CITRATE COMPOUND AND INORGANIC BUILDER SALTS SUCH AS SILICATES, CARBONATES, AND SULFATES | COLGATE-PALMOLIVE COMPANY (US) | 1978-07-25 | — | — | US | claimed |
| US-4086101-A | Photovoltaic cells | PHOTON POWER, INC. (US) | 1978-04-25 | — | — | US | claimed |
| US-4066558-A | YARN LUBRICANTS | ICI AMERICAS INC. (US) | 1978-01-03 | — | — | US | claimed |
| US-3956507-A | METHYL ESTER OF ASPARTYL PHENYLALANINE | GENERAL FOODS CORPORATION (US) | 1976-05-11 | — | — | US | claimed |