Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.61 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2275305 | 0.96 | JAK1 (0.61) | JAK1JAK2KMT2AL3MBTL1HTR6 | |
| SCHEMBL28634235 | 0.87 | JAK1 (0.52) | JAK1JAK2KMT2AL3MBTL1TYK2 | |
| SCHEMBL28621769 | 0.87 | JAK1 (0.52) | JAK1JAK2KMT2AL3MBTL1TYK2 | |
| SCHEMBL30622180 | 0.87 | JAK1 (0.52) | JAK1JAK2KMT2AL3MBTL1TYK2 | |
| SCHEMBL30622213 | 0.87 | JAK1 (0.52) | JAK1JAK2KMT2AL3MBTL1TYK2 | |
| SCHEMBL2281459 | 0.87 | JAK1 (0.44) | JAK1JAK2KMT2AL3MBTL1HTR6 | |
| SCHEMBL2281787 | 0.86 | JAK1 (0.46) | JAK1JAK2KMT2AL3MBTL1HTR6 | |
| SCHEMBL10282010 | 0.86 | JAK1 (0.46) | JAK1JAK2KMT2AL3MBTL1HTR6 | |
| SCHEMBL9953393 | 0.86 | JAK1 (0.46) | JAK1JAK2KMT2AL3MBTL1HTR6 | |
| SCHEMBL2277557 | 0.83 | JAK1 (0.50) | JAK1JAK2KMT2AL3MBTL1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |