Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622180 | 1.00 | JAK1 (0.52) | JAK1JAK2NAMPTKMT2AMEN1 | |
| SCHEMBL30622213 | 1.00 | JAK1 (0.52) | JAK1JAK2NAMPTKMT2AMEN1 | |
| SCHEMBL28621769 | 1.00 | JAK1 (0.52) | JAK1JAK2NAMPTKMT2AMEN1 | |
| SCHEMBL2272276 | 0.87 | JAK1 (0.61) | JAK1JAK2NAMPTKMT2ATYK2 | |
| SCHEMBL2275305 | 0.86 | JAK1 (0.61) | JAK1JAK2NAMPTKMT2ATYK2 | |
| SCHEMBL31212490 | 0.86 | JAK1 (0.40) | JAK1KMT2AL3MBTL1 | |
| SCHEMBL26638292 | 0.84 | JAK1 (0.39) | JAK1JAK2KMT2APOLBTYK2 | |
| SCHEMBL30798109 | 0.84 | JAK1 (0.39) | JAK1JAK2KMT2APOLBTYK2 | |
| SCHEMBL30052630 | 0.83 | JAK1 (0.41) | JAK1JAK2NAMPTKMT2AMEN1 | |
| SCHEMBL28830421 | 0.83 | JAK1 (0.41) | JAK1JAK2NAMPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396150-A | Tricyclic JANUS kinase 1 inhibitors, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2021-09-14 | — | — | CN | disclosed |