Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4315755 | 0.86 | TSHR (0.44) | KDM1ACYP11B1CYP11B2CYP19A1NISCH | |
| SCHEMBL1578071 | 0.78 | MAOA (0.42) | KDM1ACYP11B1CYP11B2GPR84ACHE | |
| SCHEMBL29714906 | 0.78 | MAOA (0.42) | KDM1ACYP11B1CYP11B2GPR84ACHE | |
| SCHEMBL29714904 | 0.78 | MAOA (0.42) | KDM1ACYP11B1CYP11B2GPR84ACHE | |
| SCHEMBL24386545 | 0.71 | KDM1A (0.46) | KDM1ACYP11B1CYP11B2CYP19A1NISCH | |
| SCHEMBL11025756 | 0.71 | KDM1A (0.46) | KDM1ACYP11B1CYP11B2CYP19A1NISCH | |
| SCHEMBL5029738 | 0.71 | KDM1A (0.46) | KDM1ACYP11B1CYP11B2CYP19A1NISCH | |
| SCHEMBL4623181 | 0.71 | KDM1A (0.50) | KDM1ACYP11B1CYP11B2CYP19A1NISCH | |
| SCHEMBL13445302 | 0.71 | KDM1A (0.46) | KDM1ACYP11B1CYP11B2CYP19A1NISCH | |
| SCHEMBL10419760 | 0.71 | KDM1A (0.46) | KDM1ACYP11B1CYP11B2CYP19A1NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137508-A | 5-HT2CReceptor agonists and compositions and methods of use | 艾尼纳制药公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-103687595-B | Novel compounds as diacylglycerol acyltransferase inhibitors | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2017-05-24 | — | — | CN | disclosed |
| EP-1853261-B1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | UNIV SAARLAND (DE) | 2017-01-11 | — | — | EP | disclosed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | disclosed |
| EP-1577288-B1 | Selective estrogen receptor modulators | EISAI R&D MAN CO LTD (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8399520-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | RADIUS HEALTH, INC. | 2012-01-05 | — | — | US | disclosed |
| US-7960412-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-06-14 | — | — | US | disclosed |
| US-20090325930-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR | RADIUS HEALTH, INC. | 2009-12-31 | — | — | US | disclosed |
| EP-1506190-A1 | (IMIDAZOL-1-YL-METHYL)-PYRIDAZINE AS NMDA RECEPTOR BLOCKER | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-16 | — | — | EP | disclosed |
| CN-1578662-A | Pyridine derivatives as nmda-receptor subtype blockers | HOFFMANN LA ROCHE (CH) | 2005-02-09 | — | — | CN | disclosed |
| EP-1443926-A1 | PYRIDINE DERIVATIVES AS NMDA-RECEPTOR SUBTYPE BLOCKERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-11 | — | — | EP | disclosed |
| US-20040068118-A1 | Conjugated aromatic compounds with a pyridine substituent | ALANINE ALEXANDER (FR) | 2004-04-08 | — | — | US | disclosed |
| US-20030229096-A1 | Substituted imidazol-pyridazine derivatives | EVOTEC INTERNATIONAL GMBH (DE) | 2003-12-11 | — | — | US | disclosed |
| WO-2003097637-A1 | (IMIDAZOL-1-YL-METHYL)-PYRIDAZINE AS NMDA RECEPTOR BLOCKER | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-27 | — | — | WO | disclosed |
| US-20030144525-A1 | Conjugated aromatic compounds with a pyridine substituent | HOFFMANN-LA ROCHE INC. | 2003-07-31 | — | — | US | disclosed |
| WO-2003037333-A1 | PYRIDINE DERIVATIVES AS NMDA-RECEPTOR SUBTYPE BLOCKERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-08 | — | — | WO | disclosed |
| EP-0871612-B1 | FUSED ISOINDOLONES AS INHIBITORS OF PROTEIN KINASE C | CEPHALON INC (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5808060-A | Fused isoindolones | CEPHALON, INC. (US) | 1998-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068118-A1 | Conjugated aromatic compounds with a pyridine substituent | GRIN2B, GRIN1, GRIN2C | KDM1A 899/4885CYP11B1 359/4885CYP11B2 317/4885 |
| US-20090325930-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR | ESR1, GPER1, ESR2 | KDM1A 286/4885CYP11B1 195/4885CYP11B2 363/4885 |
| US-20030144525-A1 | Conjugated aromatic compounds with a pyridine substituent | GRIN2B, GRIN1, GRIN2C | KDM1A 899/4885CYP11B1 359/4885CYP11B2 317/4885 |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | ESR1, GPER1, ESR2 | KDM1A 434/4885CYP11B1 214/4885CYP11B2 378/4885 |
| US-20030229096-A1 | Substituted imidazol-pyridazine derivatives | GRIN2B, GRIN2A, GRIN2C | KDM1A 2058/4885CYP11B1 323/4885CYP11B2 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.