⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8686895 | 0.95 | — | — | |
| SCHEMBL4799589 | 0.72 | ALDH1A1 (0.33) | — | |
| SCHEMBL492385 | 0.70 | ALDH1A1 (0.32) | — | |
| SCHEMBL159177 | 0.70 | ALDH1A1 (0.32) | — | |
| SCHEMBL14335463 | 0.70 | ALDH1A1 (0.32) | — | |
| SCHEMBL18386438 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL206350 | 0.66 | — | — | |
| SCHEMBL2113137 | 0.65 | — | — | |
| SCHEMBL9277035 | 0.63 | — | — | |
| SCHEMBL11382636 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699053-B | 4-hydroxy-2-phenyl-1, 3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | 东佩制药股份公司 | 2022-01-14 | — | — | CN | disclosed |
| EP-3394053-B1 | (4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL) METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPE FARM SPA (IT) | 2019-08-21 | — | — | EP | disclosed |
| US-10246448-B2 | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-04-02 | — | — | US | disclosed |
| US-20180319785-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2018-11-08 | — | — | US | disclosed |
| EP-3394053-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | Dompé farmaceutici S.p.A. (IT) | 2018-10-31 | — | — | EP | disclosed |
| WO-2017108632-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPE' FARMACEUTICI S.P.A. (IT) | 2017-06-29 | — | — | WO | disclosed |
| US-8835427-B2 | Fungicidal heterocyclic compounds | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120309752-A1 | FUNGICIDAL HETEROCYCLIC COMPOUNDS | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-06 | — | — | US | disclosed |
| EP-2521450-A1 | FUNGICIDAL HETEROCYCLIC COMPOUNDS | E.I. Du Pont De Nemours And Company (US) | 2012-11-14 | — | — | EP | disclosed |
| WO-2011085170-A1 | FUNGICIDAL HETEROCYCLIC COMPOUNDS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-07-14 | — | — | WO | disclosed |