Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 1.00 |
| ▸ | BRD4 | O60885 | 10/20 | 1.00 |
| ▸ | BRDT | Q58F21 | 5/20 | 1.00 |
| ▸ | BRD2 | P25440 | 2/20 | 1.00 |
| ▸ | BRD3 | Q15059 | 2/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.65 |
| ▸ | PRKACA | P17612 | 2/20 | 0.65 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.65 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.65 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.65 |
| ▸ | PRKCG | P05129 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22730413 | 0.94 | BRD4 (0.88) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730369 | 0.92 | MAPK14 (0.85) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730366 | 0.91 | BRD4 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730323 | 0.91 | BRD4 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730464 | 0.91 | BRD4 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730462 | 0.91 | BRD4 (0.83) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730380 | 0.91 | BRD4 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730440 | 0.90 | BRD4 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730405 | 0.90 | BRD4 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6581980 | 0.88 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200377474-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377474-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | BRDT, BRD4, BRD3 | MAPK14 2751/4885BRD4 2/4885BRDT 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.