Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 1.00 |
| ▸ | BRD4 | O60885 | 6/20 | 0.79 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.79 |
| ▸ | BRD2 | P25440 | 1/20 | 0.79 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.68 |
| ▸ | PRKACA | P17612 | 2/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.68 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.68 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.68 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.68 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.68 |
| ▸ | PRKCG | P05129 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6794576 | 0.91 | MAPK14 (0.85) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730369 | 0.91 | MAPK14 (0.85) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6791353 | 0.90 | MAPK14 (0.84) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6961445 | 0.90 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6961441 | 0.90 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6579510 | 0.89 | MAPK14 (0.80) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6952550 | 0.89 | MAPK14 (0.81) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6579077 | 0.88 | MAPK14 (0.79) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6577112 | 0.88 | MAPK14 (0.79) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730357 | 0.88 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1130358-C | Imidazole compound and preparation method and application thereof | SMITHKLINE BEECHAM CORP (US) | 2003-12-10 | — | — | CN | claimed |
| EP-0831830-B1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | claimed |
| CN-1192147-A | Imidazole compounds | SMITHKLINE BEECHAM CORP (US) | 1998-09-02 | — | — | CN | claimed |
| EP-0961618-B1 | 5-Pyrimidinyl-4-yl-Imidazole Derivate zur Behandlung von CSBP/RK/p38 vermittelten Erkrankungen | SMITHKLINE BEECHAM CORP (US) | 2004-08-04 | — | — | EP | disclosed |
| CN-1130358-C | Imidazole compound and preparation method and application thereof | SMITHKLINE BEECHAM CORP (US) | 2003-12-10 | — | — | CN | disclosed |
| CN-1382044-A | Use of cell factor inhibiting anti-inflammatory agent in rhinovirus infection | SMITHKLINE BEECHAM CORP (US) | 2002-11-27 | — | — | CN | disclosed |
| US-6369068-B1 | Amino substituted pyrimidine containing compounds | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | disclosed |
| US-6255491-B1 | CHEMICAL INTERMEDIATES SUCH AS 1-(SUBSTITUTED), 4-ARYL, 5-(3-N,N-DISUBSTITUTED AMINO-1-PROPENONE) IMIDAZOLE, USEFUL FOR MAKING 5-PYRIMIDINYL IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION | 2001-07-03 | — | — | US | disclosed |
| US-6239279-B1 | THERAPY FOR CYTOKINE SENSITIVE DISEASES | SMITHKLINE BEECHAM CORPORATION | 2001-05-29 | — | — | US | disclosed |
| US-6218537-B1 | Process for making pyridyl and pyrimidine substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION | 2001-04-17 | — | — | US | disclosed |
| US-6100399-A | Synthesis for 4-aryl-5-pyrimidine imidazole substituted compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-08 | — | — | US | disclosed |
| US-5917043-A | INTERMEDIATES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-29 | — | — | US | disclosed |
| US-5869660-A | Process of preparing imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| CN-1192147-A | Imidazole compounds | SMITHKLINE BEECHAM CORP (US) | 1998-09-02 | — | — | CN | disclosed |
| US-5739143-A | Imidazole compounds and compositions | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-14 | — | — | US | disclosed |
| US-5658903-A | Imidazole compounds, compositions and use | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |