Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.55 |
| ▸ | BRD4 | O60885 | 6/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881409 | 0.92 | MAPK14 (0.62) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL22730496 | 0.92 | MAPK14 (0.51) | MAPK14BRD4PRKD3MAP4K4PRKCA | |
| SCHEMBL22730315 | 0.91 | MAPK14 (0.53) | MAPK14BRD4PRKD3MAP4K4PRKCA | |
| SCHEMBL22730349 | 0.86 | MAPK14 (0.54) | MAPK14BRD4BRDTPRKD3MAP4K4 | |
| SCHEMBL22730541 | 0.83 | BRD4 (0.63) | MAPK14BRD4BRDT | |
| SCHEMBL22730495 | 0.82 | MAPK14 (0.71) | MAPK14BRD4BRDT | |
| SCHEMBL7884407 | 0.81 | MAPK14 (0.68) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL27545277 | 0.80 | MAPK14 (0.80) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL6876676 | 0.80 | MAPK14 (0.70) | MAPK14BRD4BRDTPRKD3MAP4K4 | |
| SCHEMBL1640742 | 0.79 | MAPK14 (0.57) | MAPK14BRD4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200377474-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377474-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | BRDT, BRD4, BRD3 | MAPK14 2751/4885BRD4 2/4885BRDT 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.