Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.52 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.52 |
| ▸ | PRKCA | P17252 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22730360 | 0.92 | MAPK14 (0.55) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D | |
| SCHEMBL22730315 | 0.92 | MAPK14 (0.53) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D | |
| SCHEMBL22730496 | 0.92 | MAPK14 (0.51) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D | |
| SCHEMBL7884407 | 0.89 | MAPK14 (0.68) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D | |
| SCHEMBL27545277 | 0.88 | MAPK14 (0.80) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D | |
| SCHEMBL6876676 | 0.87 | MAPK14 (0.70) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D | |
| SCHEMBL22712334 | 0.86 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7891764 | 0.86 | MAPK14 (0.62) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D | |
| SCHEMBL6871568 | 0.86 | MAPK14 (0.70) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D | |
| SCHEMBL7048956 | 0.85 | MAPK14 (0.70) | MAPK14PRKD3MAP4K4CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0935465-B1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-04-14 | — | — | EP | disclosed |
| EP-1314728-A1 | Pyridyl and pyrimidinyl imines as intermediates for imidazole derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-0831830-B1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1264827-A1 | Process for the preparation of Tosylbenzylformamides | SMITHKLINE BEECHAM CORPORATION (US) | 2002-12-11 | — | — | EP | disclosed |
| US-6218537-B1 | Process for making pyridyl and pyrimidine substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION | 2001-04-17 | — | — | US | disclosed |
| US-6214844-B1 | ANTIARTHRITIC AGENTS; BONE DISORDERS; ANTIINFLAMMATORY AGENTS | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |
| US-5658903-A | Imidazole compounds, compositions and use | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |