Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22731513 | 0.88 | HRH3 (0.41) | HRH3HRH1HTR2AALDH1A1CYP1A2 | |
| SCHEMBL25497517 | 0.87 | HRH3 (0.48) | HRH3CYP2D6CYP2C19HRH1HTR2A | |
| SCHEMBL22731537 | 0.81 | HRH3 (0.39) | HRH3HRH1HTR2AALDH1A1HTR2B | |
| SCHEMBL11569854 | 0.80 | — | — | |
| SCHEMBL29322718 | 0.80 | MAPK1 (0.40) | HRH3CYP2D6CYP2C19HTR2AALDH1A1 | |
| SCHEMBL21793001 | 0.80 | HRH3 (0.38) | HRH3HRH1HTR2AALDH1A1HTR2B | |
| SCHEMBL24114659 | 0.80 | HRH3 (0.38) | HRH3HRH1HTR2AALDH1A1HTR2B | |
| SCHEMBL27360376 | 0.79 | S1PR1 (0.46) | SIGMAR1S1PR1S1PR3S1PR5 | |
| SCHEMBL10961176 | 0.78 | CYP2D6 (0.41) | HRH3CYP2D6CYP2C19HRH1HTR2A | |
| SCHEMBL21310110 | 0.77 | HRH3 (0.39) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11135210-B2 | Indane-amines as PD-L1 antagonists | CHEMOCENTRYX, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200375962-A1 | INDANE-AMINES AS PD-L1 ANTAGONISTS | CHEMOCENTRYX, INC. | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200375962-A1 | INDANE-AMINES AS PD-L1 ANTAGONISTS | CD274, PDCD1LG2, PDCD1 | HRH3 11/4885CYP2D6 739/4885CYP2C19 1373/4885 |
| US-11135210-B2 | Indane-amines as PD-L1 antagonists | CD274, PDCD1LG2, PDCD1 | HRH3 11/4885CYP2D6 739/4885CYP2C19 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.