Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25986150 | 0.94 | S1PR1 (0.49) | S1PR1S1PR3S1PR5SIGMAR1S1PR4 | |
| SCHEMBL19604912 | 0.92 | S1PR1 (0.51) | S1PR1S1PR3S1PR5SIGMAR1S1PR4 | |
| SCHEMBL13564381 | 0.86 | KDM4E (0.40) | S1PR1S1PR3S1PR5SIGMAR1DRD2 | |
| SCHEMBL22731513 | 0.85 | HRH3 (0.41) | S1PR1S1PR3S1PR5SIGMAR1GNAI3 | |
| SCHEMBL16263876 | 0.84 | S1PR1 (0.47) | S1PR1S1PR3S1PR5SIGMAR1S1PR4 | |
| SCHEMBL18506727 | 0.82 | S1PR1 (0.49) | S1PR1S1PR3S1PR5SIGMAR1S1PR4 | |
| SCHEMBL24114469 | 0.81 | S1PR1 (0.34) | S1PR1S1PR3S1PR5SIGMAR1S1PR4 | |
| SCHEMBL24293538 | 0.80 | SIGMAR1 (0.33) | S1PR1S1PR3S1PR5SIGMAR1 | |
| SCHEMBL22731574 | 0.79 | HRH3 (0.37) | S1PR1S1PR3S1PR5SIGMAR1 | |
| SCHEMBL22778761 | 0.78 | S1PR1 (0.42) | S1PR1S1PR3S1PR5SIGMAR1S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015863-A1 | CBL-B INHIBITOR, COMPOSITIONS COMPRISING A CBL-B INHIBITOR IN A METHOD OF TREATING A DISEASE ASSOCIATED WITH CELL PROLIFERATION | HOTSPOT THERAPEUTICS, INC. (US) | 2024-01-18 | — | — | WO | disclosed |