Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 10/20 | 0.52 |
| ▸ | MAOB | P27338 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659394 | 0.78 | MAPT (0.81) | MAOAMAOBMAPTMEN1KMT2A | |
| SCHEMBL107978 | 0.70 | MAPT (0.67) | MAOAMAOBMAPTPRKCZ | |
| SCHEMBL4813362 | 0.70 | MAPT (0.67) | MAOAMAOBMAPTPRKCZ | |
| SCHEMBL3624616 | 0.68 | NT5E (0.72) | MAOAMAOBMAPTMEN1KMT2A | |
| SCHEMBL16181207 | 0.67 | MAPT (1.00) | MAOAMAOBMAPTEGFR | |
| SCHEMBL7456837 | 0.66 | MAOB (0.73) | MAOAMAOBPRKCZ | |
| SCHEMBL18313851 | 0.66 | GAA (1.00) | MAOAMAOBMAPTGAAMEN1 | |
| SCHEMBL17454724 | 0.64 | MAOB (0.82) | MAOAMAOBALDH1A1KDM4E | |
| SCHEMBL8179557 | 0.63 | MEN1 (0.82) | MAOAMAOBMAPTPRKCZGAA | |
| SCHEMBL15301281 | 0.63 | MEN1 (0.60) | MAOAMAOBMAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687513-B1 | DRUGS FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES | UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) | 2020-12-02 | — | — | EP | disclosed |