Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29574946 | 1.00 | F2RL1 (0.36) | F2RL1SCN9A | |
| SCHEMBL24631037 | 0.87 | F2RL1 (0.43) | F2RL1SCN9A | |
| SCHEMBL28724403 | 0.87 | F2RL1 (0.43) | F2RL1SCN9A | |
| SCHEMBL29594153 | 0.87 | F2RL1 (0.43) | F2RL1SCN9A | |
| SCHEMBL29574531 | 0.81 | F2RL1 (0.32) | F2RL1 | |
| SCHEMBL22732165 | 0.81 | F2RL1 (0.32) | F2RL1 | |
| SCHEMBL22731956 | 0.80 | DGAT1 (0.32) | — | |
| SCHEMBL30311811 | 0.79 | DGAT1 (0.34) | — | |
| SCHEMBL22717311 | 0.79 | DGAT1 (0.34) | — | |
| SCHEMBL22717739 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-B1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2023-11-08 | — | — | EP | disclosed |
| CN-114127062-A | Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta | 伊迪亚生物科学有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |