Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | MMP12 | P39900 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL393359 | 0.92 | PRKCA (0.60) | PRKCAMMP12NR1I2KCNH2SCN9A | |
| SCHEMBL393360 | 0.92 | PRKCA (0.60) | PRKCAMMP12NR1I2KCNH2SCN9A | |
| SCHEMBL394862 | 0.91 | PRKCA (0.58) | PRKCAMMP12NR1I2KCNH2SCN9A | |
| SCHEMBL394863 | 0.91 | PRKCA (0.58) | PRKCAMMP12NR1I2KCNH2SCN9A | |
| SCHEMBL14110621 | 0.91 | PRKCA (0.57) | PRKCAMMP12NR1I2KCNH2SCN9A | |
| SCHEMBL2279970 | 0.91 | PRKCA (0.59) | PRKCAMMP12NR1I2KCNH2SCN9A | |
| SCHEMBL4217906 | 0.90 | PRKCA (0.67) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| SCHEMBL2275845 | 0.88 | PRKCA (0.52) | PRKCAMMP12NR1I2KCNH2SCN9A | |
| SCHEMBL2275096 | 0.88 | PRKCA (0.57) | PRKCAMMP12NR1I2KCNH2SCN9A | |
| SCHEMBL2275820 | 0.88 | PRKCA (0.57) | PRKCAMMP12NR1I2KCNH2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |