Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 5/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM4B | O94953 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480650 | 1.00 | MAP3K12 (0.34) | MAP3K12CDK9CASP3CASP7CCNT1 | |
| SCHEMBL22716889 | 0.92 | JAK1 (0.35) | HDAC4JAK1JAK2SYKALDH1A1 | |
| SCHEMBL29567498 | 0.92 | JAK1 (0.35) | HDAC4JAK1JAK2SYKALDH1A1 | |
| SCHEMBL22735711 | 0.92 | HDAC4 (0.34) | CDK9CCNT1HDAC4JAK1JAK2 | |
| SCHEMBL29480666 | 0.92 | HDAC4 (0.34) | CDK9CCNT1HDAC4JAK1JAK2 | |
| SCHEMBL22735904 | 0.91 | KDM4A (0.36) | HDAC4GRM4KDM4AKDM4BKDM5C | |
| SCHEMBL29480485 | 0.91 | KDM4A (0.36) | HDAC4GRM4KDM4AKDM4BKDM5C | |
| SCHEMBL22736027 | 0.90 | HDAC4 (0.34) | HDAC4JAK1GRM4JAK2 | |
| SCHEMBL29480597 | 0.90 | HDAC4 (0.34) | HDAC4JAK1GRM4JAK2 | |
| SCHEMBL22735900 | 0.89 | HDAC4 (0.33) | HDAC4JAK1GRM4KDM4AKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |