Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480756 | 1.00 | GRM4 (0.32) | GRM4POLBMAPTGSK3AGSK3B | |
| SCHEMBL29480706 | 0.92 | GRM4 (0.32) | GRM4 | |
| SCHEMBL29480713 | 0.90 | GRM4 (0.30) | GRM4 | |
| SCHEMBL29480659 | 0.86 | GRM4 (0.31) | GRM4 | |
| SCHEMBL22735946 | 0.86 | GRM4 (0.31) | GRM4 | |
| SCHEMBL22736035 | 0.85 | KDM5A (0.31) | GRM4 | |
| SCHEMBL29480669 | 0.78 | GRM4 (0.31) | GRM4 | |
| SCHEMBL29480662 | 0.77 | HTT (0.41) | GRM4MAPT | |
| SCHEMBL22736542 | 0.77 | GRM4 (0.33) | GRM4 | |
| SCHEMBL29480661 | 0.76 | GRM4 (0.31) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |