Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480756 | 0.77 | GRM4 (0.32) | GRM4MAPT | |
| SCHEMBL29480706 | 0.77 | GRM4 (0.32) | GRM4 | |
| SCHEMBL22735773 | 0.77 | GRM4 (0.32) | GRM4MAPT | |
| SCHEMBL29480713 | 0.77 | GRM4 (0.30) | GRM4 | |
| SCHEMBL22736327 | 0.77 | KCNJ1 (0.38) | GRM4HTR2BMTNR1AKCNH2 | |
| SCHEMBL29480741 | 0.77 | KCNJ1 (0.38) | GRM4HTR2BMTNR1AKCNH2 | |
| SCHEMBL22735911 | 0.76 | GRM4 (0.35) | HTTGRM4MAPTALDH1A1HTR2B | |
| SCHEMBL29480744 | 0.76 | LMNA (0.44) | GRM4 | |
| SCHEMBL29480689 | 0.76 | GRM4 (0.35) | HTTGRM4MAPTALDH1A1HTR2B | |
| SCHEMBL22736126 | 0.76 | EGLN1 (0.37) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |