Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | JAK1 | P23458 | 4/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 2/20 | 0.32 |
| ▸ | GCG | P01275 | 3/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22736499 | 0.85 | JAK2 (0.34) | JAK2JAK1HDAC4JAK3 | |
| SCHEMBL22735886 | 0.83 | JAK2 (0.33) | JAK2JAK1HDAC4JAK3 | |
| SCHEMBL22736177 | 0.83 | PDK2 (0.36) | PDK2JAK2JAK1GCGRGCG | |
| SCHEMBL22736028 | 0.83 | PDK2 (0.36) | PDK2JAK2JAK1GCGRGCG | |
| SCHEMBL29480488 | 0.82 | GRM4 (0.33) | JAK2HDAC4 | |
| SCHEMBL22735729 | 0.82 | GRM4 (0.33) | JAK2HDAC4 | |
| SCHEMBL22736504 | 0.81 | MAPK1 (0.38) | — | |
| SCHEMBL29480563 | 0.81 | MAPK1 (0.38) | — | |
| SCHEMBL22736183 | 0.81 | GRM4 (0.35) | JAK1HDAC4 | |
| SCHEMBL29480474 | 0.81 | GRM4 (0.35) | JAK1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | claimed |
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |