Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 4/20 | 0.35 |
| ▸ | KDM4B | O94953 | 4/20 | 0.35 |
| ▸ | KDM5C | P41229 | 4/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.35 |
| ▸ | MELK | Q14680 | 2/20 | 0.33 |
| ▸ | CCNC | P24863 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.32 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.32 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480563 | 1.00 | MAPK1 (0.38) | MAPK1GRM4KDM4AKDM4BKDM5C | |
| SCHEMBL22716882 | 0.92 | MAPK1 (0.36) | MAPK1GRM4KDM4AKDM4BKDM5C | |
| SCHEMBL29480559 | 0.92 | MAPK1 (0.36) | MAPK1GRM4KDM4AKDM4BKDM5C | |
| SCHEMBL22735886 | 0.83 | JAK2 (0.33) | GRM4 | |
| SCHEMBL22736499 | 0.82 | JAK2 (0.34) | GRM4 | |
| SCHEMBL22735865 | 0.81 | PDK2 (0.37) | — | |
| SCHEMBL29480598 | 0.81 | GCG (0.33) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22735905 | 0.81 | GCG (0.33) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736186 | 0.80 | MAPK1 (0.42) | MAPK1GRM4KDM4AKDM4BKDM5C | |
| SCHEMBL29567713 | 0.80 | MAPK1 (0.42) | MAPK1GRM4KDM4AKDM4BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |